Generation of a human induced pluripotent stem cell line (UALGi001-A) from a patient with Left-Ventricular Noncompaction Cardiomyopathy

Left Ventricular Noncompaction Cardiomyopathy (LVNC) is characterized by excessive trabeculation of the left ventricle. To date, mutations in more than 40 genes have been associated with LVNC, however exact mechanisms underlying disease remain unknown. Here, we describe an induced pluripotent stem cell (iPSC) line (UALGi001-A) from a LVNC patient (LVNC-iPSC) that does not present most commonly (van Waning et al., 2019). The LVNC-iPSC exhibited full pluripotency and differentiation potential, retained normal karyotype after reprogramming. This vitro cellular model will be useful to study molecular, genetic functional aspects LVNC.